TYROSINE LOCALIZATION IN HYPOPHYSEAL ALPHA CELLS
نویسندگان
چکیده
منابع مشابه
Lck-dependent tyrosine phosphorylation of diacylglycerol kinase alpha regulates its membrane association in T cells.
TCR engagement triggers phospholipase Cgamma1 activation through the Lck-ZAP70-linker of activated T cell adaptor protein pathway. This leads to generation of diacylglycerol (DAG) and mobilization of intracellular Ca(2+), both essential for TCR-dependent transcriptional responses. TCR ligation also elicits transient recruitment of DAG kinase alpha (DGKalpha) to the lymphocyte plasma membrane to...
متن کاملLHRH-induced tyrosine phosphorylation and MAP kinase activation in alpha T3-1 cells.
Protein tyrosine kinases regulate numerous signal transduction pathways, including those controlling cell growth [l] . Apart from the growth factor receptor tyrosine kinases, certain G proteincoupled receptors also are capable of stimulating protein tyrosine phosphorylations in their target cells [2]. Another group of protein kinases that become activated in response to various extracellular st...
متن کاملAlpha-synuclein activation of protein phosphatase 2A reduces tyrosine hydroxylase phosphorylation in dopaminergic cells.
alpha-Synuclein is an abundant presynaptic protein implicated in neuronal plasticity and neurodegenerative diseases. Although the function of alpha-synuclein is not thoroughly elucidated, we found that alpha-synuclein regulates dopamine synthesis by binding to and inhibiting tyrosine hydroxylase, the rate limiting enzyme in dopamine synthesis. Understanding alpha-synuclein function in dopaminer...
متن کاملIntracellular Localization of Tyrosine Kinase Substrates beneath Crossfnked Surface Immunoglobulins in B Cells
Crosslinking of surface immunoglobulins (sIg) in B cells led to the accumulation of submembranal phosphotyrosine, which was followed morphologically with the PY20 antiphosphotyrosine monoclonal antibody. Phosphotyrosine was not detected before sIg crosslinking. After sIg crosslinking, phosphotyrosine-containing proteins were redistributed from scattered small clusters near the plasma membrane t...
متن کاملIntracellular localization of tyrosine kinase substrates beneath crosslinked surface immunoglobulins in B cells
Crosslinking of surface immunoglobulins (sIg) in B cells led to the accumulation of submembranal phosphotyrosine, which was followed morphologically with the PY20 antiphosphotyrosine monoclonal antibody. Phosphotyrosine was not detected before sIg crosslinking. After sIg crosslinking, phosphotyrosine-containing proteins were redistributed from scattered small clusters near the plasma membrane t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Histochemistry & Cytochemistry
سال: 1960
ISSN: 0022-1554,1551-5044
DOI: 10.1177/8.2.138